The Schultz-Dale Anaphylactic Test for Carcinoma Antigen

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1. Typical lethal anaphylactic shock has been produced in guinea pigs by means of the specific carbohydrate derived from a human strain of tubercle bacillus. The phenomenon has been observed in animals both actively and passively sensitized. 2. Typical contractions have been evoked in the isolated uterus of guinea pigs upon the addition of the specific carbohydrate to the bath. 3. True anaphyla...

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BACKGROUND BCG, a potent inducer of Th1 immune response, has been suggested to suppress Th2 response which is known to mediate IgE-mediated allergic disorders, in particular allergic asthma. Schultz-Dale reaction is known to be a model of IgE-mediated hypersensitivity. This study was done to investigate whether BCG infection suppresses the Schultz-Dale reaction by inhibiting Th2 response and al...

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ژورنال

عنوان ژورنال: BMJ

سال: 1959

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.5152.615